Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 121223..121848 Replicon plasmid pEND_Eco 16002
Accession NZ_CP126945
Organism Escherichia coli O1:K1:H7 strain APEC E16002

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQA28_RS26090 Protein ID WP_000911333.1
Coordinates 121223..121621 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag QQA28_RS26095 Protein ID WP_000450520.1
Coordinates 121621..121848 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA28_RS26075 (117554) 117554..118063 + 510 WP_000628105.1 conjugal transfer entry exclusion protein TraS -
QQA28_RS26080 (118077) 118077..118808 + 732 WP_000850416.1 conjugal transfer complement resistance protein TraT -
QQA28_RS26085 (119061) 119061..121214 + 2154 WP_039025869.1 type IV conjugative transfer system coupling protein TraD -
QQA28_RS26090 (121223) 121223..121621 - 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
QQA28_RS26095 (121621) 121621..121848 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / vat 1..191373 191373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T283263 WP_000911333.1 NZ_CP126945:c121621-121223 [Escherichia coli O1:K1:H7]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT283263 WP_000450520.1 NZ_CP126945:c121848-121621 [Escherichia coli O1:K1:H7]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References