Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4626934..4627431 Replicon chromosome
Accession NZ_CP126944
Organism Escherichia coli O1:K1:H7 strain APEC E16002

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQA28_RS22935 Protein ID WP_001173343.1
Coordinates 4626934..4627107 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QQA28_RS22940 Protein ID WP_001312331.1
Coordinates 4627135..4627431 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA28_RS22925 (4623604) 4623604..4625061 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QQA28_RS22930 (4625298) 4625298..4626815 + 1518 WP_000003806.1 lysine--tRNA ligase -
QQA28_RS22935 (4626934) 4626934..4627107 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQA28_RS22940 (4627135) 4627135..4627431 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQA28_RS22945 (4627659) 4627659..4627931 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQA28_RS22950 (4627943) 4627943..4628173 - 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
QQA28_RS22955 (4628354) 4628354..4629985 + 1632 WP_001216482.1 sensor histidine kinase -
QQA28_RS22960 (4629982) 4629982..4630701 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283255 WP_001173343.1 NZ_CP126944:c4627107-4626934 [Escherichia coli O1:K1:H7]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT283255 WP_001312331.1 NZ_CP126944:c4627431-4627135 [Escherichia coli O1:K1:H7]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References