Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4351837..4352651 Replicon chromosome
Accession NZ_CP126944
Organism Escherichia coli O1:K1:H7 strain APEC E16002

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QQA28_RS21515 Protein ID WP_001054376.1
Coordinates 4351837..4352094 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QQA28_RS21520 Protein ID WP_001309181.1
Coordinates 4352106..4352651 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA28_RS21490 (4347125) 4347125..4348231 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
QQA28_RS21495 (4348296) 4348296..4349276 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QQA28_RS21500 (4349386) 4349386..4349591 + 206 Protein_4214 HNH endonuclease -
QQA28_RS21505 (4349859) 4349859..4351099 - 1241 Protein_4215 helicase YjhR -
QQA28_RS21510 (4351215) 4351215..4351346 + 132 WP_001309182.1 hypothetical protein -
QQA28_RS21515 (4351837) 4351837..4352094 + 258 WP_001054376.1 YjhX family toxin Toxin
QQA28_RS21520 (4352106) 4352106..4352651 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
QQA28_RS21525 (4352707) 4352707..4353453 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QQA28_RS21530 (4353622) 4353622..4353840 + 219 Protein_4220 hypothetical protein -
QQA28_RS21535 (4353878) 4353878..4353994 + 117 Protein_4221 VOC family protein -
QQA28_RS21540 (4354239) 4354239..4355360 + 1122 WP_000010830.1 M42 family metallopeptidase -
QQA28_RS21545 (4355357) 4355357..4355635 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QQA28_RS21550 (4355647) 4355647..4356960 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4344331..4360875 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T283253 WP_001054376.1 NZ_CP126944:4351837-4352094 [Escherichia coli O1:K1:H7]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT283253 WP_001309181.1 NZ_CP126944:4352106-4352651 [Escherichia coli O1:K1:H7]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References