Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3693503..3694121 Replicon chromosome
Accession NZ_CP126944
Organism Escherichia coli O1:K1:H7 strain APEC E16002

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA28_RS18370 Protein ID WP_001291435.1
Coordinates 3693903..3694121 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA28_RS18365 Protein ID WP_000344800.1
Coordinates 3693503..3693877 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA28_RS18355 (3688593) 3688593..3689786 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQA28_RS18360 (3689809) 3689809..3692958 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA28_RS18365 (3693503) 3693503..3693877 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA28_RS18370 (3693903) 3693903..3694121 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA28_RS18375 (3694295) 3694295..3694846 + 552 WP_000102543.1 maltose O-acetyltransferase -
QQA28_RS18380 (3694962) 3694962..3695432 + 471 WP_000136192.1 YlaC family protein -
QQA28_RS18385 (3695596) 3695596..3697146 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA28_RS18390 (3697188) 3697188..3697541 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QQA28_RS18400 (3697920) 3697920..3698231 + 312 WP_000409908.1 MGMT family protein -
QQA28_RS18405 (3698262) 3698262..3698834 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283246 WP_001291435.1 NZ_CP126944:3693903-3694121 [Escherichia coli O1:K1:H7]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283246 WP_000344800.1 NZ_CP126944:3693503-3693877 [Escherichia coli O1:K1:H7]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References