Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2583394..2584982 Replicon chromosome
Accession NZ_CP126944
Organism Escherichia coli O1:K1:H7 strain APEC E16002

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag QQA28_RS12745 Protein ID WP_001125475.1
Coordinates 2583660..2584982 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QQA28_RS12740 Protein ID WP_001332145.1
Coordinates 2583394..2583660 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA28_RS12725 (2579762) 2579762..2581213 + 1452 WP_000854637.1 tagaturonate reductase -
QQA28_RS12730 (2581410) 2581410..2582324 + 915 WP_001306069.1 bestrophin family protein -
QQA28_RS12735 (2582328) 2582328..2583086 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
QQA28_RS12740 (2583394) 2583394..2583660 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QQA28_RS12745 (2583660) 2583660..2584982 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QQA28_RS12750 (2585292) 2585292..2585474 - 183 Protein_2500 hypothetical protein -
QQA28_RS12755 (2585608) 2585608..2586390 + 783 WP_001221834.1 SDR family oxidoreductase -
QQA28_RS12760 (2586634) 2586634..2586741 - 108 Protein_2502 hypothetical protein -
QQA28_RS12765 (2587166) 2587166..2587729 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
QQA28_RS12770 (2588091) 2588091..2588801 + 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T283243 WP_001125475.1 NZ_CP126944:2583660-2584982 [Escherichia coli O1:K1:H7]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT283243 WP_001332145.1 NZ_CP126944:2583394-2583660 [Escherichia coli O1:K1:H7]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References