Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1024347..1025001 Replicon chromosome
Accession NZ_CP126944
Organism Escherichia coli O1:K1:H7 strain APEC E16002

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QQA28_RS05060 Protein ID WP_000244781.1
Coordinates 1024594..1025001 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QQA28_RS05055 Protein ID WP_000354046.1
Coordinates 1024347..1024613 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA28_RS05035 (1020435) 1020435..1021868 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
QQA28_RS05040 (1021913) 1021913..1022224 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QQA28_RS05045 (1022388) 1022388..1023047 + 660 WP_000250274.1 hemolysin III family protein -
QQA28_RS05050 (1023124) 1023124..1024104 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
QQA28_RS05055 (1024347) 1024347..1024613 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QQA28_RS05060 (1024594) 1024594..1025001 + 408 WP_000244781.1 protein YgfX Toxin
QQA28_RS05065 (1025041) 1025041..1025562 - 522 WP_001055874.1 flavodoxin FldB -
QQA28_RS05070 (1025674) 1025674..1026570 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
QQA28_RS05075 (1026595) 1026595..1027305 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQA28_RS05080 (1027311) 1027311..1029044 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T283236 WP_000244781.1 NZ_CP126944:1024594-1025001 [Escherichia coli O1:K1:H7]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT283236 WP_000354046.1 NZ_CP126944:1024347-1024613 [Escherichia coli O1:K1:H7]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References