Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 91129..91772 Replicon plasmid pEND_Eco 18006
Accession NZ_CP126943
Organism Escherichia coli O1:K1:H7 strain APEC E18006

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag QQA29_RS26005 Protein ID WP_001034044.1
Coordinates 91356..91772 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag QQA29_RS26000 Protein ID WP_001261286.1
Coordinates 91129..91359 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA29_RS25985 (86266) 86266..86496 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
QQA29_RS25990 (86493) 86493..86909 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
QQA29_RS25995 (86954) 86954..90748 - 3795 WP_001144732.1 hypothetical protein -
QQA29_RS26000 (91129) 91129..91359 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QQA29_RS26005 (91356) 91356..91772 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
QQA29_RS26010 (91847) 91847..93412 + 1566 WP_001128474.1 AAA family ATPase -
QQA29_RS26015 (93397) 93397..94419 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat 1..192699 192699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T283230 WP_001034044.1 NZ_CP126943:91356-91772 [Escherichia coli O1:K1:H7]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT283230 WP_001261286.1 NZ_CP126943:91129-91359 [Escherichia coli O1:K1:H7]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References