Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3142085..3142903 | Replicon | chromosome |
| Accession | NC_018658 | ||
| Organism | Escherichia coli O104:H4 str. 2011C-3493 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0E0Y102 |
| Locus tag | O3K_RS15485 | Protein ID | WP_000771609.1 |
| Coordinates | 3142085..3142459 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0E0Y470 |
| Locus tag | O3K_RS15490 | Protein ID | WP_001285568.1 |
| Coordinates | 3142550..3142903 (-) | Length | 118 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| O3K_RS15445 | 3137089..3137580 | - | 492 | WP_001297187.1 | DUF1097 domain-containing protein | - |
| O3K_RS15450 | 3137682..3138236 | - | 555 | WP_001001902.1 | molecular chaperone YcdY | - |
| O3K_RS15455 | 3138260..3138997 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| O3K_RS15460 | 3139052..3139990 | - | 939 | WP_000351313.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| O3K_RS15470 | 3140461..3141303 | - | 843 | WP_001274560.1 | DUF4942 domain-containing protein | - |
| O3K_RS15475 | 3141388..3141585 | - | 198 | WP_000839270.1 | DUF957 domain-containing protein | - |
| O3K_RS15480 | 3141597..3142088 | - | 492 | WP_000976860.1 | hypothetical protein | - |
| O3K_RS15485 | 3142085..3142459 | - | 375 | WP_000771609.1 | TA system toxin CbtA family protein | Toxin |
| O3K_RS15490 | 3142550..3142903 | - | 354 | WP_001285568.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| O3K_RS15495 | 3142979..3143200 | - | 222 | WP_000692357.1 | DUF987 domain-containing protein | - |
| O3K_RS15500 | 3143263..3143739 | - | 477 | WP_001186756.1 | RadC family protein | - |
| O3K_RS15505 | 3143755..3144228 | - | 474 | WP_000855049.1 | antirestriction protein | - |
| O3K_RS15510 | 3144322..3144567 | - | 246 | WP_001164966.1 | hypothetical protein | - |
| O3K_RS15515 | 3144567..3145388 | - | 822 | WP_001241709.1 | DUF945 domain-containing protein | - |
| O3K_RS15520 | 3145609..3146019 | - | 411 | WP_000846716.1 | hypothetical protein | - |
| O3K_RS15525 | 3146035..3146718 | - | 684 | WP_000775510.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14006.09 Da Isoelectric Point: 7.2652
>T28322 WP_000771609.1 NC_018658:c3142459-3142085 [Escherichia coli O104:H4 str. 2011C-3493]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T28322 NC_018658:c3142459-3142085 [Escherichia coli O104:H4 str. 2011C-3493]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA
Antitoxin
Download Length: 118 a.a. Molecular weight: 13064.82 Da Isoelectric Point: 5.9541
>AT28322 WP_001285568.1 NC_018658:c3142903-3142550 [Escherichia coli O104:H4 str. 2011C-3493]
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
Download Length: 354 bp
>AT28322 NC_018658:c3142903-3142550 [Escherichia coli O104:H4 str. 2011C-3493]
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y102 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y470 |