Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4614820..4615654 Replicon chromosome
Accession NZ_CP126942
Organism Escherichia coli O1:K1:H7 strain APEC E18006

Toxin (Protein)


Gene name yeeV Uniprot ID B7MK10
Locus tag QQA29_RS22890 Protein ID WP_000854820.1
Coordinates 4615277..4615654 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag QQA29_RS22885 Protein ID WP_001285610.1
Coordinates 4614820..4615188 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA29_RS22845 (4610541) 4610541..4611221 + 681 WP_001278649.1 WYL domain-containing protein -
QQA29_RS22850 (4611372) 4611372..4612049 + 678 WP_001097565.1 hypothetical protein -
QQA29_RS22855 (4612055) 4612055..4612288 + 234 WP_000883181.1 DUF905 family protein -
QQA29_RS22860 (4612378) 4612378..4613196 + 819 WP_001175155.1 DUF932 domain-containing protein -
QQA29_RS22865 (4613222) 4613222..4613362 - 141 WP_000997937.1 hypothetical protein -
QQA29_RS22870 (4613462) 4613462..4613941 + 480 WP_000706978.1 antirestriction protein -
QQA29_RS22875 (4613956) 4613956..4614432 + 477 WP_001186193.1 RadC family protein -
QQA29_RS22880 (4614519) 4614519..4614740 + 222 WP_000692347.1 DUF987 domain-containing protein -
QQA29_RS22885 (4614820) 4614820..4615188 + 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QQA29_RS22890 (4615277) 4615277..4615654 + 378 WP_000854820.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QQA29_RS22895 (4615651) 4615651..4615848 + 198 Protein_4488 DUF5983 family protein -
QQA29_RS22900 (4615876) 4615876..4616073 + 198 WP_085949158.1 DUF957 domain-containing protein -
QQA29_RS22905 (4616158) 4616158..4616718 + 561 Protein_4490 DUF4942 domain-containing protein -
QQA29_RS22910 (4617553) 4617553..4619091 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14043.12 Da        Isoelectric Point: 7.8839

>T283219 WP_000854820.1 NZ_CP126942:4615277-4615654 [Escherichia coli O1:K1:H7]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT283219 WP_001285610.1 NZ_CP126942:4614820-4615188 [Escherichia coli O1:K1:H7]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2KXX6

Antitoxin

Source ID Structure

References