Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4351346..4352160 Replicon chromosome
Accession NZ_CP126942
Organism Escherichia coli O1:K1:H7 strain APEC E18006

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QQA29_RS21510 Protein ID WP_001054376.1
Coordinates 4351346..4351603 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QQA29_RS21515 Protein ID WP_001309181.1
Coordinates 4351615..4352160 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA29_RS21485 (4346634) 4346634..4347740 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
QQA29_RS21490 (4347805) 4347805..4348785 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QQA29_RS21495 (4348895) 4348895..4349100 + 206 Protein_4213 HNH endonuclease -
QQA29_RS21500 (4349368) 4349368..4350608 - 1241 Protein_4214 helicase YjhR -
QQA29_RS21505 (4350724) 4350724..4350855 + 132 WP_001309182.1 hypothetical protein -
QQA29_RS21510 (4351346) 4351346..4351603 + 258 WP_001054376.1 YjhX family toxin Toxin
QQA29_RS21515 (4351615) 4351615..4352160 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
QQA29_RS21520 (4352216) 4352216..4352962 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QQA29_RS21525 (4353131) 4353131..4353349 + 219 Protein_4219 hypothetical protein -
QQA29_RS21530 (4353387) 4353387..4353503 + 117 Protein_4220 VOC family protein -
QQA29_RS21535 (4353748) 4353748..4354869 + 1122 WP_000010830.1 M42 family metallopeptidase -
QQA29_RS21540 (4354866) 4354866..4355144 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QQA29_RS21545 (4355156) 4355156..4356469 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4343840..4360384 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T283218 WP_001054376.1 NZ_CP126942:4351346-4351603 [Escherichia coli O1:K1:H7]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT283218 WP_001309181.1 NZ_CP126942:4351615-4352160 [Escherichia coli O1:K1:H7]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References