Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3693013..3693631 Replicon chromosome
Accession NZ_CP126942
Organism Escherichia coli O1:K1:H7 strain APEC E18006

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA29_RS18365 Protein ID WP_001291435.1
Coordinates 3693413..3693631 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA29_RS18360 Protein ID WP_000344800.1
Coordinates 3693013..3693387 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA29_RS18350 (3688103) 3688103..3689296 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQA29_RS18355 (3689319) 3689319..3692468 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA29_RS18360 (3693013) 3693013..3693387 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA29_RS18365 (3693413) 3693413..3693631 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA29_RS18370 (3693805) 3693805..3694356 + 552 WP_000102543.1 maltose O-acetyltransferase -
QQA29_RS18375 (3694472) 3694472..3694942 + 471 WP_000136192.1 YlaC family protein -
QQA29_RS18380 (3695106) 3695106..3696656 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA29_RS18385 (3696698) 3696698..3697051 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QQA29_RS18395 (3697430) 3697430..3697741 + 312 WP_000409908.1 MGMT family protein -
QQA29_RS18400 (3697772) 3697772..3698344 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283211 WP_001291435.1 NZ_CP126942:3693413-3693631 [Escherichia coli O1:K1:H7]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283211 WP_000344800.1 NZ_CP126942:3693013-3693387 [Escherichia coli O1:K1:H7]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References