Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2583284..2584872 Replicon chromosome
Accession NZ_CP126942
Organism Escherichia coli O1:K1:H7 strain APEC E18006

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag QQA29_RS12745 Protein ID WP_001125475.1
Coordinates 2583550..2584872 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QQA29_RS12740 Protein ID WP_001332145.1
Coordinates 2583284..2583550 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA29_RS12725 (2579652) 2579652..2581103 + 1452 WP_000854637.1 tagaturonate reductase -
QQA29_RS12730 (2581300) 2581300..2582214 + 915 WP_001306069.1 bestrophin family protein -
QQA29_RS12735 (2582218) 2582218..2582976 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
QQA29_RS12740 (2583284) 2583284..2583550 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QQA29_RS12745 (2583550) 2583550..2584872 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QQA29_RS12750 (2585182) 2585182..2585364 - 183 Protein_2500 hypothetical protein -
QQA29_RS12755 (2585498) 2585498..2586280 + 783 WP_001221834.1 SDR family oxidoreductase -
QQA29_RS12760 (2586524) 2586524..2586631 - 108 Protein_2502 hypothetical protein -
QQA29_RS12765 (2587056) 2587056..2587619 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
QQA29_RS12770 (2587981) 2587981..2588691 + 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T283208 WP_001125475.1 NZ_CP126942:2583550-2584872 [Escherichia coli O1:K1:H7]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT283208 WP_001332145.1 NZ_CP126942:2583284-2583550 [Escherichia coli O1:K1:H7]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References