Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4729147..4730191 Replicon chromosome
Accession NZ_CP126940
Organism Escherichia coli O2:K1:H7 strain APEC E18055

Toxin (Protein)


Gene name panT Uniprot ID A0A839B4R0
Locus tag QQA30_RS23460 Protein ID WP_000019187.1
Coordinates 4729147..4729695 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag QQA30_RS23465 Protein ID WP_000287252.1
Coordinates 4729718..4730191 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA30_RS23420 (4724367) 4724367..4724870 - 504 WP_000357060.1 hypothetical protein -
QQA30_RS23425 (4725343) 4725343..4725705 + 363 WP_258134318.1 protein YfdP -
QQA30_RS23430 (4725771) 4725771..4726595 + 825 WP_061352757.1 DUF2303 family protein -
QQA30_RS23435 (4726723) 4726723..4727259 + 537 WP_000008174.1 5'-deoxynucleotidase -
QQA30_RS23440 (4727250) 4727250..4727612 + 363 WP_001242714.1 phage protein -
QQA30_RS23445 (4727993) 4727993..4728232 + 240 Protein_4592 DUF551 domain-containing protein -
QQA30_RS23450 (4728232) 4728232..4728804 + 573 WP_021567854.1 3'-5' exonuclease -
QQA30_RS23455 (4728841) 4728841..4729113 + 273 WP_001093913.1 pyocin activator PrtN family protein -
QQA30_RS23460 (4729147) 4729147..4729695 - 549 WP_000019187.1 hypothetical protein Toxin
QQA30_RS23465 (4729718) 4729718..4730191 - 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
QQA30_RS23470 (4730714) 4730714..4731229 + 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
QQA30_RS23475 (4731271) 4731271..4731480 - 210 WP_001296638.1 CsbD family protein -
QQA30_RS23480 (4731596) 4731596..4732921 - 1326 WP_001296637.1 MATE family efflux transporter DinF -
QQA30_RS23485 (4732994) 4732994..4733602 - 609 WP_000646078.1 transcriptional repressor LexA -
QQA30_RS23490 (4733712) 4733712..4734080 - 369 WP_000002899.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4687459..4733602 46143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 19966.42 Da        Isoelectric Point: 4.5662

>T283187 WP_000019187.1 NZ_CP126940:c4729695-4729147 [Escherichia coli O2:K1:H7]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQIFKSAFEPSNHESDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT283187 WP_000287252.1 NZ_CP126940:c4730191-4729718 [Escherichia coli O2:K1:H7]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839B4R0

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References