Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3739033..3739651 Replicon chromosome
Accession NZ_CP126940
Organism Escherichia coli O2:K1:H7 strain APEC E18055

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA30_RS18620 Protein ID WP_001291435.1
Coordinates 3739433..3739651 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA30_RS18615 Protein ID WP_000344800.1
Coordinates 3739033..3739407 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA30_RS18605 (3734123) 3734123..3735316 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQA30_RS18610 (3735339) 3735339..3738488 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA30_RS18615 (3739033) 3739033..3739407 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA30_RS18620 (3739433) 3739433..3739651 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA30_RS18625 (3739825) 3739825..3740376 + 552 WP_000102543.1 maltose O-acetyltransferase -
QQA30_RS18630 (3740492) 3740492..3740962 + 471 WP_000136192.1 YlaC family protein -
QQA30_RS18635 (3741126) 3741126..3742676 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA30_RS18640 (3742718) 3742718..3743071 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QQA30_RS18650 (3743450) 3743450..3743761 + 312 WP_000409908.1 MGMT family protein -
QQA30_RS18655 (3743792) 3743792..3744364 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283182 WP_001291435.1 NZ_CP126940:3739433-3739651 [Escherichia coli O2:K1:H7]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283182 WP_000344800.1 NZ_CP126940:3739033-3739407 [Escherichia coli O2:K1:H7]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References