Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2629291..2630879 Replicon chromosome
Accession NZ_CP126940
Organism Escherichia coli O2:K1:H7 strain APEC E18055

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag QQA30_RS12995 Protein ID WP_001125475.1
Coordinates 2629557..2630879 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QQA30_RS12990 Protein ID WP_001332145.1
Coordinates 2629291..2629557 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA30_RS12975 (2625659) 2625659..2627110 + 1452 WP_000854637.1 tagaturonate reductase -
QQA30_RS12980 (2627307) 2627307..2628221 + 915 WP_001306069.1 bestrophin family protein -
QQA30_RS12985 (2628225) 2628225..2628983 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
QQA30_RS12990 (2629291) 2629291..2629557 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QQA30_RS12995 (2629557) 2629557..2630879 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QQA30_RS13000 (2631189) 2631189..2631371 - 183 Protein_2551 hypothetical protein -
QQA30_RS13005 (2631505) 2631505..2632287 + 783 WP_001221834.1 SDR family oxidoreductase -
QQA30_RS13010 (2632531) 2632531..2632638 - 108 Protein_2553 hypothetical protein -
QQA30_RS13015 (2633063) 2633063..2633626 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
QQA30_RS13020 (2633988) 2633988..2634698 + 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T283179 WP_001125475.1 NZ_CP126940:2629557-2630879 [Escherichia coli O2:K1:H7]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT283179 WP_001332145.1 NZ_CP126940:2629291-2629557 [Escherichia coli O2:K1:H7]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References