Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1121841..1122424 Replicon chromosome
Accession NZ_CP126940
Organism Escherichia coli O2:K1:H7 strain APEC E18055

Toxin (Protein)


Gene name mazF Uniprot ID V0SV58
Locus tag QQA30_RS05460 Protein ID WP_000254750.1
Coordinates 1122089..1122424 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag QQA30_RS05455 Protein ID WP_000581937.1
Coordinates 1121841..1122089 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA30_RS05445 (1118180) 1118180..1119481 + 1302 WP_000046816.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
QQA30_RS05450 (1119529) 1119529..1121763 + 2235 WP_000226815.1 GTP pyrophosphokinase -
QQA30_RS05455 (1121841) 1121841..1122089 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QQA30_RS05460 (1122089) 1122089..1122424 + 336 WP_000254750.1 endoribonuclease MazF Toxin
QQA30_RS05465 (1122496) 1122496..1123287 + 792 WP_001071651.1 nucleoside triphosphate pyrophosphohydrolase -
QQA30_RS05470 (1123515) 1123515..1125152 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
QQA30_RS05475 (1125240) 1125240..1126538 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12067.95 Da        Isoelectric Point: 8.2618

>T283172 WP_000254750.1 NZ_CP126940:1122089-1122424 [Escherichia coli O2:K1:H7]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT283172 WP_000581937.1 NZ_CP126940:1121841-1122089 [Escherichia coli O2:K1:H7]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SV58

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References