Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 967899..968553 Replicon chromosome
Accession NZ_CP126940
Organism Escherichia coli O2:K1:H7 strain APEC E18055

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QQA30_RS04825 Protein ID WP_000244781.1
Coordinates 968146..968553 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QQA30_RS04820 Protein ID WP_000354046.1
Coordinates 967899..968165 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA30_RS04800 (963987) 963987..965420 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
QQA30_RS04805 (965465) 965465..965776 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QQA30_RS04810 (965940) 965940..966599 + 660 WP_000250274.1 hemolysin III family protein -
QQA30_RS04815 (966676) 966676..967656 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
QQA30_RS04820 (967899) 967899..968165 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QQA30_RS04825 (968146) 968146..968553 + 408 WP_000244781.1 protein YgfX Toxin
QQA30_RS04830 (968593) 968593..969114 - 522 WP_001055874.1 flavodoxin FldB -
QQA30_RS04835 (969226) 969226..970122 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
QQA30_RS04840 (970147) 970147..970857 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQA30_RS04845 (970863) 970863..972596 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T283171 WP_000244781.1 NZ_CP126940:968146-968553 [Escherichia coli O2:K1:H7]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT283171 WP_000354046.1 NZ_CP126940:967899-968165 [Escherichia coli O2:K1:H7]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References