283167

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4382350..4382847 Replicon chromosome
Accession NZ_CP126937
Organism Escherichia coli O2:K1:H4 strain APEC E19019

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQA31_RS21415 Protein ID WP_001173343.1
Coordinates 4382350..4382523 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QQA31_RS21420 Protein ID WP_001312331.1
Coordinates 4382551..4382847 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA31_RS21405 (4379020) 4379020..4380477 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QQA31_RS21410 (4380714) 4380714..4382231 + 1518 WP_000003806.1 lysine--tRNA ligase -
QQA31_RS21415 (4382350) 4382350..4382523 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQA31_RS21420 (4382551) 4382551..4382847 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQA31_RS21425 (4383075) 4383075..4383347 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQA31_RS21430 (4383359) 4383359..4383589 - 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
QQA31_RS21435 (4383770) 4383770..4385401 + 1632 WP_001216482.1 sensor histidine kinase -
QQA31_RS21440 (4385398) 4385398..4386117 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283167 WP_001173343.1 NZ_CP126937:c4382523-4382350 [Escherichia coli O2:K1:H4]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT283167 WP_001312331.1 NZ_CP126937:c4382847-4382551 [Escherichia coli O2:K1:H4]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References