Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4147995..4148809 Replicon chromosome
Accession NZ_CP126937
Organism Escherichia coli O2:K1:H4 strain APEC E19019

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QQA31_RS20245 Protein ID WP_001054376.1
Coordinates 4147995..4148252 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A8E0IVE5
Locus tag QQA31_RS20250 Protein ID WP_001350781.1
Coordinates 4148264..4148809 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA31_RS20220 (4143283) 4143283..4144389 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
QQA31_RS20225 (4144454) 4144454..4145434 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QQA31_RS20230 (4145544) 4145544..4145749 + 206 Protein_3962 HNH endonuclease -
QQA31_RS20235 (4146017) 4146017..4147257 - 1241 Protein_3963 helicase YjhR -
QQA31_RS20240 (4147373) 4147373..4147504 + 132 WP_001309182.1 hypothetical protein -
QQA31_RS20245 (4147995) 4147995..4148252 + 258 WP_001054376.1 YjhX family toxin Toxin
QQA31_RS20250 (4148264) 4148264..4148809 + 546 WP_001350781.1 N-acetyltransferase Antitoxin
QQA31_RS20255 (4148865) 4148865..4149611 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QQA31_RS20260 (4149780) 4149780..4149998 + 219 Protein_3968 hypothetical protein -
QQA31_RS20265 (4150036) 4150036..4150152 + 117 Protein_3969 VOC family protein -
QQA31_RS20270 (4150397) 4150397..4151518 + 1122 WP_000010829.1 M42 family metallopeptidase -
QQA31_RS20275 (4151515) 4151515..4151793 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QQA31_RS20280 (4151805) 4151805..4153118 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4137780..4157033 19253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T283166 WP_001054376.1 NZ_CP126937:4147995-4148252 [Escherichia coli O2:K1:H4]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19974.91 Da        Isoelectric Point: 6.3277

>AT283166 WP_001350781.1 NZ_CP126937:4148264-4148809 [Escherichia coli O2:K1:H4]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References