Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3526526..3527144 Replicon chromosome
Accession NZ_CP126937
Organism Escherichia coli O2:K1:H4 strain APEC E19019

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA31_RS17240 Protein ID WP_001291435.1
Coordinates 3526926..3527144 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA31_RS17235 Protein ID WP_000344800.1
Coordinates 3526526..3526900 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA31_RS17225 (3521616) 3521616..3522809 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQA31_RS17230 (3522832) 3522832..3525981 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA31_RS17235 (3526526) 3526526..3526900 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA31_RS17240 (3526926) 3526926..3527144 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA31_RS17245 (3527318) 3527318..3527869 + 552 WP_000102543.1 maltose O-acetyltransferase -
QQA31_RS17250 (3527985) 3527985..3528455 + 471 WP_000136192.1 YlaC family protein -
QQA31_RS17255 (3528619) 3528619..3530169 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA31_RS17260 (3530211) 3530211..3530564 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QQA31_RS17270 (3530943) 3530943..3531254 + 312 WP_000409908.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3531284..3532612 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283159 WP_001291435.1 NZ_CP126937:3526926-3527144 [Escherichia coli O2:K1:H4]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283159 WP_000344800.1 NZ_CP126937:3526526-3526900 [Escherichia coli O2:K1:H4]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References