Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2460650..2462238 Replicon chromosome
Accession NZ_CP126937
Organism Escherichia coli O2:K1:H4 strain APEC E19019

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag QQA31_RS11970 Protein ID WP_001125475.1
Coordinates 2460916..2462238 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QQA31_RS11965 Protein ID WP_001332145.1
Coordinates 2460650..2460916 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA31_RS11950 (2457018) 2457018..2458469 + 1452 WP_001513806.1 tagaturonate reductase -
QQA31_RS11955 (2458666) 2458666..2459580 + 915 WP_001306069.1 bestrophin family protein -
QQA31_RS11960 (2459584) 2459584..2460342 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
QQA31_RS11965 (2460650) 2460650..2460916 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QQA31_RS11970 (2460916) 2460916..2462238 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QQA31_RS11975 (2462413) 2462413..2462784 - 372 WP_000795853.1 hypothetical protein -
QQA31_RS11980 (2462830) 2462830..2463297 - 468 WP_000218697.1 hypothetical protein -
QQA31_RS11985 (2463409) 2463409..2463831 - 423 WP_000089313.1 hypothetical protein -
QQA31_RS11990 (2463931) 2463931..2464377 - 447 WP_000527682.1 helix-turn-helix transcriptional regulator -
QQA31_RS11995 (2464549) 2464549..2465601 + 1053 WP_000568107.1 phage/plasmid replication protein, II/X family -
QQA31_RS12000 (2465613) 2465613..2465930 + 318 WP_000073835.1 DNA-binding protein -
QQA31_RS12005 (2465933) 2465933..2466184 + 252 WP_000381239.1 membrane protein -
QQA31_RS12010 (2466219) 2466219..2466452 + 234 WP_000473544.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T283156 WP_001125475.1 NZ_CP126937:2460916-2462238 [Escherichia coli O2:K1:H4]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT283156 WP_001332145.1 NZ_CP126937:2460650-2460916 [Escherichia coli O2:K1:H4]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References