Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1022274..1022928 Replicon chromosome
Accession NZ_CP126937
Organism Escherichia coli O2:K1:H4 strain APEC E19019

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QQA31_RS05085 Protein ID WP_000244781.1
Coordinates 1022521..1022928 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag QQA31_RS05080 Protein ID WP_016239318.1
Coordinates 1022274..1022540 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA31_RS05060 (1018362) 1018362..1019795 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
QQA31_RS05065 (1019840) 1019840..1020151 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QQA31_RS05070 (1020315) 1020315..1020974 + 660 WP_000250274.1 hemolysin III family protein -
QQA31_RS05075 (1021051) 1021051..1022031 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
QQA31_RS05080 (1022274) 1022274..1022540 + 267 WP_016239318.1 FAD assembly factor SdhE Antitoxin
QQA31_RS05085 (1022521) 1022521..1022928 + 408 WP_000244781.1 protein YgfX Toxin
QQA31_RS05090 (1022968) 1022968..1023489 - 522 WP_001055874.1 flavodoxin FldB -
QQA31_RS05095 (1023601) 1023601..1024497 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
QQA31_RS05100 (1024522) 1024522..1025232 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQA31_RS05105 (1025238) 1025238..1026971 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T283148 WP_000244781.1 NZ_CP126937:1022521-1022928 [Escherichia coli O2:K1:H4]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10573.20 Da        Isoelectric Point: 5.1599

>AT283148 WP_016239318.1 NZ_CP126937:1022274-1022540 [Escherichia coli O2:K1:H4]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDILSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure

References