Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 744764..745596 Replicon chromosome
Accession NZ_CP126937
Organism Escherichia coli O2:K1:H4 strain APEC E19019

Toxin (Protein)


Gene name yeeV Uniprot ID F4TJC5
Locus tag QQA31_RS03700 Protein ID WP_001094452.1
Coordinates 745222..745596 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TJC4
Locus tag QQA31_RS03695 Protein ID WP_001285579.1
Coordinates 744764..745132 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA31_RS03675 (742513) 742513..743331 + 819 WP_001564116.1 DUF932 domain-containing protein -
QQA31_RS03680 (743423) 743423..743908 + 486 WP_000206669.1 antirestriction protein -
QQA31_RS03685 (743924) 743924..744400 + 477 WP_001186706.1 RadC family protein -
QQA31_RS03690 (744463) 744463..744684 + 222 WP_000692345.1 DUF987 domain-containing protein -
QQA31_RS03695 (744764) 744764..745132 + 369 WP_001285579.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QQA31_RS03700 (745222) 745222..745596 + 375 WP_001094452.1 TA system toxin CbtA family protein Toxin
QQA31_RS03705 (745593) 745593..746084 + 492 WP_000976868.1 DUF5983 family protein -
QQA31_RS03710 (746096) 746096..746293 + 198 WP_000772035.1 DUF957 domain-containing protein -
QQA31_RS03715 (746390) 746390..747235 + 846 WP_021539310.1 DUF4942 domain-containing protein -
QQA31_RS03725 (747535) 747535..748041 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
QQA31_RS03730 (748120) 748120..749961 - 1842 WP_000437380.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14014.86 Da        Isoelectric Point: 7.2920

>T283146 WP_001094452.1 NZ_CP126937:745222-745596 [Escherichia coli O2:K1:H4]
MNTLPDTHVREASRCSSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSTDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13580.39 Da        Isoelectric Point: 7.3223

>AT283146 WP_001285579.1 NZ_CP126937:744764-745132 [Escherichia coli O2:K1:H4]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7YIM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8DWX2

References