Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 66572..67119 Replicon plasmid pEND_Eco19057-1
Accession NZ_CP126935
Organism Escherichia coli O78:H4 strain APEC E19057

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag QQA26_RS24365 Protein ID WP_001384452.1
Coordinates 66841..67119 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag QQA26_RS24360 Protein ID WP_032181987.1
Coordinates 66572..66841 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA26_RS24340 (62216) 62216..62749 - 534 WP_001306770.1 transcription termination/antitermination NusG family protein -
QQA26_RS24345 (63191) 63191..63478 - 288 WP_000074849.1 conjugal transfer protein TraA -
QQA26_RS24350 (63396) 63396..63626 - 231 WP_228772074.1 ash family protein -
QQA26_RS24355 (64632) 64632..65663 + 1032 WP_044706701.1 plasmid replication initiator RepA -
QQA26_RS24360 (66572) 66572..66841 + 270 WP_032181987.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QQA26_RS24365 (66841) 66841..67119 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
QQA26_RS24370 (67159) 67159..68007 + 849 WP_001057996.1 3'-5' exonuclease -
QQA26_RS24375 (68124) 68124..68597 + 474 WP_077128838.1 hypothetical protein -
QQA26_RS24380 (69074) 69074..69340 - 267 WP_000627831.1 hypothetical protein -
QQA26_RS24385 (69340) 69340..69834 - 495 WP_001350009.1 hypothetical protein -
QQA26_RS24390 (69890) 69890..70492 - 603 WP_289266615.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - afaC-I 1..110406 110406


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T283135 WP_001384452.1 NZ_CP126935:66841-67119 [Escherichia coli O78:H4]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10177.47 Da        Isoelectric Point: 6.7251

>AT283135 WP_032181987.1 NZ_CP126935:66572-66841 [Escherichia coli O78:H4]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVEQQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure

References