Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4874396..4875014 Replicon chromosome
Accession NZ_CP126934
Organism Escherichia coli O78:H4 strain APEC E19057

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA26_RS23985 Protein ID WP_001291435.1
Coordinates 4874396..4874614 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA26_RS23990 Protein ID WP_000344800.1
Coordinates 4874640..4875014 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA26_RS23950 (4869685) 4869685..4870257 + 573 WP_000779831.1 YbaY family lipoprotein -
QQA26_RS23955 (4870288) 4870288..4870599 - 312 WP_000409911.1 MGMT family protein -
QQA26_RS23965 (4870978) 4870978..4871331 + 354 Protein_4674 DUF1428 family protein -
QQA26_RS23970 (4871373) 4871373..4872923 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA26_RS23975 (4873087) 4873087..4873557 - 471 WP_000136192.1 YlaC family protein -
QQA26_RS23980 (4873673) 4873673..4874224 - 552 WP_000102568.1 maltose O-acetyltransferase -
QQA26_RS23985 (4874396) 4874396..4874614 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA26_RS23990 (4874640) 4874640..4875014 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA26_RS23995 (4875560) 4875560..4878709 - 3150 WP_136719285.1 efflux RND transporter permease AcrB -
QQA26_RS24000 (4878732) 4878732..4879925 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283130 WP_001291435.1 NZ_CP126934:c4874614-4874396 [Escherichia coli O78:H4]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283130 WP_000344800.1 NZ_CP126934:c4875014-4874640 [Escherichia coli O78:H4]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References