Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4198282..4198877 Replicon chromosome
Accession NZ_CP126934
Organism Escherichia coli O78:H4 strain APEC E19057

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QQA26_RS20735 Protein ID WP_000239579.1
Coordinates 4198527..4198877 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QQA26_RS20730 Protein ID WP_001223208.1
Coordinates 4198282..4198533 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA26_RS20720 (4193946) 4193946..4197725 + 3780 WP_000060921.1 autotransporter assembly complex protein TamB -
QQA26_RS20725 (4197728) 4197728..4198069 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QQA26_RS20730 (4198282) 4198282..4198533 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QQA26_RS20735 (4198527) 4198527..4198877 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QQA26_RS20740 (4198957) 4198957..4199487 - 531 WP_000055072.1 inorganic diphosphatase -
QQA26_RS20745 (4199797) 4199797..4200753 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QQA26_RS20750 (4201063) 4201063..4202565 + 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
QQA26_RS20755 (4202579) 4202579..4203601 + 1023 WP_001339490.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T283129 WP_000239579.1 NZ_CP126934:4198527-4198877 [Escherichia coli O78:H4]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT283129 WP_001223208.1 NZ_CP126934:4198282-4198533 [Escherichia coli O78:H4]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References