Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4093803..4094300 Replicon chromosome
Accession NZ_CP126934
Organism Escherichia coli O78:H4 strain APEC E19057

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQA26_RS20205 Protein ID WP_001173343.1
Coordinates 4094127..4094300 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag QQA26_RS20200 Protein ID WP_001425728.1
Coordinates 4093803..4094099 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA26_RS20180 (4090534) 4090534..4091253 - 720 WP_000611288.1 two-component system response regulator DcuR -
QQA26_RS20185 (4091250) 4091250..4092881 - 1632 WP_001216487.1 sensor histidine kinase -
QQA26_RS20190 (4093062) 4093062..4093292 + 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
QQA26_RS20195 (4093304) 4093304..4093576 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQA26_RS20200 (4093803) 4093803..4094099 + 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQA26_RS20205 (4094127) 4094127..4094300 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQA26_RS20210 (4094419) 4094419..4095936 - 1518 WP_001295074.1 lysine--tRNA ligase -
QQA26_RS20215 (4096173) 4096173..4097630 - 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283128 WP_001173343.1 NZ_CP126934:4094127-4094300 [Escherichia coli O78:H4]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT283128 WP_001425728.1 NZ_CP126934:4093803-4094099 [Escherichia coli O78:H4]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References