Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3344415..3345001 Replicon chromosome
Accession NZ_CP126934
Organism Escherichia coli O78:H4 strain APEC E19057

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag QQA26_RS16765 Protein ID WP_042014162.1
Coordinates 3344771..3345001 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QQA26_RS16760 Protein ID WP_000593555.1
Coordinates 3344415..3344774 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA26_RS16735 (3340547) 3340547..3341491 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
QQA26_RS16740 (3341488) 3341488..3342321 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QQA26_RS16745 (3342321) 3342321..3343085 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
QQA26_RS16750 (3343082) 3343082..3343888 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
QQA26_RS16755 (3343894) 3343894..3344295 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QQA26_RS16760 (3344415) 3344415..3344774 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QQA26_RS16765 (3344771) 3344771..3345001 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
QQA26_RS16770 (3345105) 3345105..3346229 - 1125 WP_001314210.1 ABC transporter permease -
QQA26_RS16775 (3346229) 3346229..3348964 - 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T283127 WP_042014162.1 NZ_CP126934:c3345001-3344771 [Escherichia coli O78:H4]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT283127 WP_000593555.1 NZ_CP126934:c3344774-3344415 [Escherichia coli O78:H4]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References