Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2263915..2264540 Replicon chromosome
Accession NZ_CP126934
Organism Escherichia coli O78:H4 strain APEC E19057

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQA26_RS11410 Protein ID WP_000911330.1
Coordinates 2263915..2264313 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QQA26_RS11415 Protein ID WP_000450524.1
Coordinates 2264313..2264540 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA26_RS11390 (2259793) 2259793..2259993 + 201 WP_000383836.1 YpfN family protein -
QQA26_RS11395 (2260103) 2260103..2260801 - 699 WP_000679823.1 esterase -
QQA26_RS11400 (2260875) 2260875..2262890 - 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
QQA26_RS11405 (2262905) 2262905..2263768 - 864 WP_001267507.1 neutral zinc metallopeptidase -
QQA26_RS11410 (2263915) 2263915..2264313 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QQA26_RS11415 (2264313) 2264313..2264540 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QQA26_RS11420 (2264694) 2264694..2265407 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QQA26_RS11425 (2265620) 2265620..2266654 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QQA26_RS11430 (2266671) 2266671..2267549 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QQA26_RS11435 (2267695) 2267695..2268267 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QQA26_RS11440 (2268267) 2268267..2268737 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T283119 WP_000911330.1 NZ_CP126934:c2264313-2263915 [Escherichia coli O78:H4]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT283119 WP_000450524.1 NZ_CP126934:c2264540-2264313 [Escherichia coli O78:H4]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References