283106

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 134996..135531 Replicon plasmid pEND_Eco 19025-1
Accession NZ_CP126932
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name relE Uniprot ID Q3YTD6
Locus tag QQA25_RS25570 Protein ID WP_000222766.1
Coordinates 135244..135531 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag QQA25_RS25565 Protein ID WP_001132900.1
Coordinates 134996..135247 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS25540 (130470) 130470..130937 + 468 Protein_140 plasmid replication initiator RepA -
QQA25_RS25545 (130990) 130990..131667 + 678 WP_001339397.1 IS66-like element accessory protein TnpA -
QQA25_RS25550 (131667) 131667..132014 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
QQA25_RS25555 (132034) 132034..133605 + 1572 WP_289257139.1 IS66 family transposase -
QQA25_RS25560 (133636) 133636..134034 + 399 Protein_144 plasmid replication initiator RepA -
QQA25_RS25565 (134996) 134996..135247 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QQA25_RS25570 (135244) 135244..135531 + 288 WP_000222766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQA25_RS25580 (137080) 137080..137247 + 168 Protein_148 helix-turn-helix transcriptional regulator -
QQA25_RS25585 (137218) 137218..137412 - 195 Protein_149 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / vat 1..160439 160439
- inside IScluster/Tn - - 127857..137013 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11147.23 Da        Isoelectric Point: 10.5832

>T283106 WP_000222766.1 NZ_CP126932:135244-135531 [Escherichia coli O78:H51]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT283106 WP_001132900.1 NZ_CP126932:134996-135247 [Escherichia coli O78:H51]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDZ2

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References