Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 118340..118965 Replicon plasmid pEND_Eco 19025-1
Accession NZ_CP126932
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQA25_RS25470 Protein ID WP_000911333.1
Coordinates 118340..118738 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag QQA25_RS25475 Protein ID WP_000450520.1
Coordinates 118738..118965 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS25455 (114671) 114671..115180 + 510 WP_021525551.1 conjugal transfer entry exclusion protein TraS -
QQA25_RS25460 (115194) 115194..115925 + 732 WP_000850422.1 conjugal transfer complement resistance protein TraT -
QQA25_RS25465 (116178) 116178..118331 + 2154 Protein_125 type IV conjugative transfer system coupling protein TraD -
QQA25_RS25470 (118340) 118340..118738 - 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
QQA25_RS25475 (118738) 118738..118965 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / vat 1..160439 160439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T283105 WP_000911333.1 NZ_CP126932:c118738-118340 [Escherichia coli O78:H51]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT283105 WP_000450520.1 NZ_CP126932:c118965-118738 [Escherichia coli O78:H51]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References