Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 876..1423 Replicon plasmid pEND_Eco 19025-1
Accession NZ_CP126932
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QQA25_RS24850 Protein ID WP_097309154.1
Coordinates 1145..1423 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QQA25_RS24845 Protein ID WP_000079941.1
Coordinates 876..1145 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS24845 (876) 876..1145 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QQA25_RS24850 (1145) 1145..1423 + 279 WP_097309154.1 type II toxin-antitoxin system toxin YacB Toxin
QQA25_RS24855 (1469) 1469..2317 + 849 WP_001058005.1 3'-5' exonuclease -
QQA25_RS24860 (2434) 2434..2916 + 483 WP_001311056.1 hypothetical protein -
QQA25_RS24865 (3218) 3218..3565 + 348 WP_000142437.1 DUF6404 family protein -
QQA25_RS24870 (3643) 3643..3943 - 301 Protein_6 hypothetical protein -
QQA25_RS24875 (4124) 4124..5065 + 942 WP_001312841.1 3-deoxy-7-phosphoheptulonate synthase -
QQA25_RS24880 (5025) 5025..5159 + 135 WP_249531455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / vat 1..160439 160439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10799.42 Da        Isoelectric Point: 8.4615

>T283101 WP_097309154.1 NZ_CP126932:1145-1423 [Escherichia coli O78:H51]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTVQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT283101 WP_000079941.1 NZ_CP126932:876-1145 [Escherichia coli O78:H51]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References