Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4608377..4608874 Replicon chromosome
Accession NZ_CP126931
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQA25_RS22510 Protein ID WP_001173343.1
Coordinates 4608377..4608550 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QQA25_RS22515 Protein ID WP_000398619.1
Coordinates 4608578..4608874 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS22500 (4605047) 4605047..4606504 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QQA25_RS22505 (4606741) 4606741..4608258 + 1518 WP_001295074.1 lysine--tRNA ligase -
QQA25_RS22510 (4608377) 4608377..4608550 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQA25_RS22515 (4608578) 4608578..4608874 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQA25_RS22520 (4609101) 4609101..4609373 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQA25_RS22525 (4609385) 4609385..4609615 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
QQA25_RS22530 (4609796) 4609796..4611427 + 1632 WP_001216461.1 sensor histidine kinase -
QQA25_RS22535 (4611424) 4611424..4612143 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(B) - 4549047..4608874 59827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283099 WP_001173343.1 NZ_CP126931:c4608550-4608377 [Escherichia coli O78:H51]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT283099 WP_000398619.1 NZ_CP126931:c4608874-4608578 [Escherichia coli O78:H51]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References