Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4440245..4440840 Replicon chromosome
Accession NZ_CP126931
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QQA25_RS21675 Protein ID WP_000239579.1
Coordinates 4440245..4440595 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QQA25_RS21680 Protein ID WP_001223208.1
Coordinates 4440589..4440840 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS21655 (4435521) 4435521..4436543 - 1023 WP_001339490.1 ABC transporter permease -
QQA25_RS21660 (4436557) 4436557..4438059 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
QQA25_RS21665 (4438369) 4438369..4439325 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QQA25_RS21670 (4439635) 4439635..4440165 + 531 WP_000055072.1 inorganic diphosphatase -
QQA25_RS21675 (4440245) 4440245..4440595 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QQA25_RS21680 (4440589) 4440589..4440840 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QQA25_RS21685 (4441053) 4441053..4441394 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QQA25_RS21690 (4441397) 4441397..4445176 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T283097 WP_000239579.1 NZ_CP126931:c4440595-4440245 [Escherichia coli O78:H51]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT283097 WP_001223208.1 NZ_CP126931:c4440840-4440589 [Escherichia coli O78:H51]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References