Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3732099..3732936 Replicon chromosome
Accession NZ_CP126931
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QQA25_RS18230 Protein ID WP_000227784.1
Coordinates 3732394..3732936 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QQA25_RS18225 Protein ID WP_001297137.1
Coordinates 3732099..3732410 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS18200 (3727119) 3727119..3728066 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
QQA25_RS18205 (3728088) 3728088..3730079 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QQA25_RS18210 (3730069) 3730069..3730683 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QQA25_RS18215 (3730683) 3730683..3731012 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QQA25_RS18220 (3731024) 3731024..3731914 + 891 WP_000971336.1 heme o synthase -
QQA25_RS18225 (3732099) 3732099..3732410 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QQA25_RS18230 (3732394) 3732394..3732936 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QQA25_RS18235 (3732992) 3732992..3733927 - 936 WP_001297127.1 tetratricopeptide repeat protein -
QQA25_RS18240 (3734335) 3734335..3735699 + 1365 WP_001000978.1 MFS transporter -
QQA25_RS18245 (3735827) 3735827..3736318 - 492 WP_001138904.1 nucleotide binding protein YajQ -
QQA25_RS18250 (3736459) 3736459..3737667 + 1209 WP_001352368.1 IS4-like element ISVsa5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3736459..3737667 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T283095 WP_000227784.1 NZ_CP126931:3732394-3732936 [Escherichia coli O78:H51]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT283095 WP_001297137.1 NZ_CP126931:3732099-3732410 [Escherichia coli O78:H51]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References