Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3698022..3698640 Replicon chromosome
Accession NZ_CP126931
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA25_RS18060 Protein ID WP_001291435.1
Coordinates 3698422..3698640 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA25_RS18055 Protein ID WP_000344800.1
Coordinates 3698022..3698396 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS18045 (3693111) 3693111..3694304 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQA25_RS18050 (3694327) 3694327..3697476 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA25_RS18055 (3698022) 3698022..3698396 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA25_RS18060 (3698422) 3698422..3698640 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA25_RS18065 (3698812) 3698812..3699363 + 552 WP_000102568.1 maltose O-acetyltransferase -
QQA25_RS18070 (3699479) 3699479..3699949 + 471 WP_000136192.1 YlaC family protein -
QQA25_RS18075 (3700113) 3700113..3701663 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA25_RS18080 (3701705) 3701705..3702058 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QQA25_RS18090 (3702437) 3702437..3702748 + 312 WP_000409911.1 MGMT family protein -
QQA25_RS18095 (3702779) 3702779..3703351 - 573 WP_289257051.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283094 WP_001291435.1 NZ_CP126931:3698422-3698640 [Escherichia coli O78:H51]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283094 WP_000344800.1 NZ_CP126931:3698022-3698396 [Escherichia coli O78:H51]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References