Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2668559..2669197 Replicon chromosome
Accession NZ_CP126931
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QQA25_RS12995 Protein ID WP_000813794.1
Coordinates 2669021..2669197 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QQA25_RS12990 Protein ID WP_001270286.1
Coordinates 2668559..2668975 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS12970 (2663711) 2663711..2664652 - 942 WP_001251319.1 ABC transporter permease -
QQA25_RS12975 (2664653) 2664653..2665666 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QQA25_RS12980 (2665684) 2665684..2666829 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QQA25_RS12985 (2667074) 2667074..2668480 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
QQA25_RS12990 (2668559) 2668559..2668975 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QQA25_RS12995 (2669021) 2669021..2669197 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QQA25_RS13000 (2669419) 2669419..2669649 + 231 WP_000494244.1 YncJ family protein -
QQA25_RS13005 (2669741) 2669741..2671702 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QQA25_RS13010 (2671775) 2671775..2672311 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
QQA25_RS13015 (2672364) 2672364..2673578 + 1215 WP_001349372.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2673618..2674883 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T283093 WP_000813794.1 NZ_CP126931:c2669197-2669021 [Escherichia coli O78:H51]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT283093 WP_001270286.1 NZ_CP126931:c2668975-2668559 [Escherichia coli O78:H51]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References