Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1407564..1408189 Replicon chromosome
Accession NZ_CP126931
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQA25_RS06835 Protein ID WP_000911330.1
Coordinates 1407791..1408189 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QQA25_RS06830 Protein ID WP_000450524.1
Coordinates 1407564..1407791 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS06805 (1403367) 1403367..1403837 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QQA25_RS06810 (1403837) 1403837..1404409 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QQA25_RS06815 (1404555) 1404555..1405433 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QQA25_RS06820 (1405450) 1405450..1406484 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QQA25_RS06825 (1406697) 1406697..1407410 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QQA25_RS06830 (1407564) 1407564..1407791 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QQA25_RS06835 (1407791) 1407791..1408189 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QQA25_RS06840 (1408336) 1408336..1409199 + 864 WP_001267508.1 neutral zinc metallopeptidase -
QQA25_RS06845 (1409214) 1409214..1411229 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
QQA25_RS06850 (1411303) 1411303..1412001 + 699 WP_000679823.1 esterase -
QQA25_RS06855 (1412111) 1412111..1412311 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T283085 WP_000911330.1 NZ_CP126931:1407791-1408189 [Escherichia coli O78:H51]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT283085 WP_000450524.1 NZ_CP126931:1407564-1407791 [Escherichia coli O78:H51]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References