Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 313667..314253 Replicon chromosome
Accession NZ_CP126931
Organism Escherichia coli O78:H51 strain APEC E19025

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag QQA25_RS01415 Protein ID WP_042014162.1
Coordinates 313667..313897 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QQA25_RS01420 Protein ID WP_000593555.1
Coordinates 313894..314253 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA25_RS01405 (309704) 309704..312439 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
QQA25_RS01410 (312439) 312439..313563 + 1125 WP_001314210.1 ABC transporter permease -
QQA25_RS01415 (313667) 313667..313897 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
QQA25_RS01420 (313894) 313894..314253 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QQA25_RS01425 (314373) 314373..314774 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QQA25_RS01430 (314780) 314780..315586 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
QQA25_RS01435 (315583) 315583..316347 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
QQA25_RS01440 (316347) 316347..317180 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QQA25_RS01445 (317177) 317177..318121 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T283079 WP_042014162.1 NZ_CP126931:313667-313897 [Escherichia coli O78:H51]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT283079 WP_000593555.1 NZ_CP126931:313894-314253 [Escherichia coli O78:H51]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References