Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 176472..177097 Replicon plasmid pEND_Eco 12053-1
Accession NZ_CP126929
Organism Escherichia coli O2:K1:H4 strain APEC E12053

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQA27_RS24860 Protein ID WP_000911333.1
Coordinates 176699..177097 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag QQA27_RS24855 Protein ID WP_000450520.1
Coordinates 176472..176699 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA27_RS24855 (176472) 176472..176699 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
QQA27_RS24860 (176699) 176699..177097 + 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
QQA27_RS24865 (177106) 177106..179259 - 2154 WP_000009379.1 type IV conjugative transfer system coupling protein TraD -
QQA27_RS24870 (179512) 179512..180243 - 732 WP_000850416.1 conjugal transfer complement resistance protein TraT -
QQA27_RS24875 (180257) 180257..180766 - 510 WP_000628105.1 conjugal transfer entry exclusion protein TraS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat 1..189727 189727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T283077 WP_000911333.1 NZ_CP126929:176699-177097 [Escherichia coli O2:K1:H4]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT283077 WP_000450520.1 NZ_CP126929:176472-176699 [Escherichia coli O2:K1:H4]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References