Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4384996..4385493 Replicon chromosome
Accession NZ_CP126928
Organism Escherichia coli O2:K1:H4 strain APEC E12053

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQA27_RS21520 Protein ID WP_001173343.1
Coordinates 4384996..4385169 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag QQA27_RS21525 Protein ID WP_289245828.1
Coordinates 4385197..4385493 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA27_RS21510 (4381666) 4381666..4383123 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QQA27_RS21515 (4383360) 4383360..4384877 + 1518 WP_000003806.1 lysine--tRNA ligase -
QQA27_RS21520 (4384996) 4384996..4385169 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQA27_RS21525 (4385197) 4385197..4385493 - 297 WP_289245828.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQA27_RS21530 (4385721) 4385721..4385993 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQA27_RS21535 (4386005) 4386005..4386235 - 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
QQA27_RS21540 (4386416) 4386416..4388047 + 1632 WP_001216482.1 sensor histidine kinase -
QQA27_RS21545 (4388044) 4388044..4388763 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283067 WP_001173343.1 NZ_CP126928:c4385169-4384996 [Escherichia coli O2:K1:H4]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11380.85 Da        Isoelectric Point: 4.1705

>AT283067 WP_289245828.1 NZ_CP126928:c4385493-4385197 [Escherichia coli O2:K1:H4]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNSSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References