283059

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3558907..3559525 Replicon chromosome
Accession NZ_CP126928
Organism Escherichia coli O2:K1:H4 strain APEC E12053

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA27_RS17535 Protein ID WP_001291435.1
Coordinates 3559307..3559525 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA27_RS17530 Protein ID WP_000344800.1
Coordinates 3558907..3559281 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA27_RS17520 (3553997) 3553997..3555190 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQA27_RS17525 (3555213) 3555213..3558362 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA27_RS17530 (3558907) 3558907..3559281 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA27_RS17535 (3559307) 3559307..3559525 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA27_RS17540 (3559699) 3559699..3560250 + 552 WP_000102543.1 maltose O-acetyltransferase -
QQA27_RS17545 (3560366) 3560366..3560836 + 471 WP_000136192.1 YlaC family protein -
QQA27_RS17550 (3561000) 3561000..3562550 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA27_RS17555 (3562592) 3562592..3562945 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QQA27_RS17565 (3563324) 3563324..3563635 + 312 WP_000409908.1 MGMT family protein -
QQA27_RS17570 (3563666) 3563666..3564238 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283059 WP_001291435.1 NZ_CP126928:3559307-3559525 [Escherichia coli O2:K1:H4]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283059 WP_000344800.1 NZ_CP126928:3558907-3559281 [Escherichia coli O2:K1:H4]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References