Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 947711..948365 Replicon chromosome
Accession NZ_CP126928
Organism Escherichia coli O2:K1:H4 strain APEC E12053

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QQA27_RS04670 Protein ID WP_000244781.1
Coordinates 947958..948365 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QQA27_RS04665 Protein ID WP_000354046.1
Coordinates 947711..947977 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA27_RS04645 (943799) 943799..945232 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
QQA27_RS04650 (945277) 945277..945588 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QQA27_RS04655 (945752) 945752..946411 + 660 WP_000250274.1 hemolysin III family protein -
QQA27_RS04660 (946488) 946488..947468 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
QQA27_RS04665 (947711) 947711..947977 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QQA27_RS04670 (947958) 947958..948365 + 408 WP_000244781.1 protein YgfX Toxin
QQA27_RS04675 (948405) 948405..948926 - 522 WP_001055874.1 flavodoxin FldB -
QQA27_RS04680 (949038) 949038..949934 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
QQA27_RS04685 (949959) 949959..950669 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQA27_RS04690 (950675) 950675..952408 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T283047 WP_000244781.1 NZ_CP126928:947958-948365 [Escherichia coli O2:K1:H4]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT283047 WP_000354046.1 NZ_CP126928:947711-947977 [Escherichia coli O2:K1:H4]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References