Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 831747..832548 | Replicon | chromosome |
Accession | NZ_CP126928 | ||
Organism | Escherichia coli O2:K1:H4 strain APEC E12053 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | D8EBK0 |
Locus tag | QQA27_RS04035 | Protein ID | WP_001094436.1 |
Coordinates | 831747..832124 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | B7MN76 |
Locus tag | QQA27_RS04040 | Protein ID | WP_015953067.1 |
Coordinates | 832171..832548 (-) | Length | 126 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QQA27_RS04010 (827950) | 827950..828120 | - | 171 | Protein_788 | IS110 family transposase | - |
QQA27_RS04015 (828517) | 828517..830052 | - | 1536 | WP_000492897.1 | EAL domain-containing protein | - |
QQA27_RS04020 (830123) | 830123..830968 | - | 846 | WP_001280513.1 | DUF4942 domain-containing protein | - |
QQA27_RS04025 (831053) | 831053..831250 | - | 198 | WP_000839254.1 | DUF957 domain-containing protein | - |
QQA27_RS04030 (831262) | 831262..831750 | - | 489 | WP_000761714.1 | DUF5983 family protein | - |
QQA27_RS04035 (831747) | 831747..832124 | - | 378 | WP_001094436.1 | TA system toxin CbtA family protein | Toxin |
QQA27_RS04040 (832171) | 832171..832548 | - | 378 | WP_015953067.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
QQA27_RS04045 (832627) | 832627..832848 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
QQA27_RS04050 (832917) | 832917..833393 | - | 477 | WP_001186756.1 | RadC family protein | - |
QQA27_RS04055 (833408) | 833408..833893 | - | 486 | WP_000860054.1 | antirestriction protein | - |
QQA27_RS04060 (833984) | 833984..834802 | - | 819 | WP_001175142.1 | DUF932 domain-containing protein | - |
QQA27_RS04065 (834892) | 834892..835125 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
QQA27_RS04070 (835131) | 835131..835808 | - | 678 | WP_001097312.1 | hypothetical protein | - |
QQA27_RS04075 (835956) | 835956..836636 | - | 681 | WP_001282927.1 | WYL domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / kpsM / kpsT / neuD / neuB / neuA / neuC / neuE / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / papI / papB / papA / papH / papC / papC / papD / papJ / papK / papE / papF / papG | 690947..878581 | 187634 | |
- | flank | IS/Tn | - | - | 827950..828054 | 104 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13958.84 Da Isoelectric Point: 6.8603
>T283046 WP_001094436.1 NZ_CP126928:c832124-831747 [Escherichia coli O2:K1:H4]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ
Download Length: 378 bp
Antitoxin
Download Length: 126 a.a. Molecular weight: 13766.60 Da Isoelectric Point: 6.2021
>AT283046 WP_015953067.1 NZ_CP126928:c832548-832171 [Escherichia coli O2:K1:H4]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E2L1N0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5Z3CIS0 |