Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 153266..153891 Replicon plasmid pEND_Eco 19035-1
Accession NZ_CP126927
Organism Escherichia coli O2:K1:H5 strain APEC E19035

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQA32_RS26890 Protein ID WP_000911333.1
Coordinates 153493..153891 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QQA32_RS26885 Protein ID WP_169051904.1
Coordinates 153266..153493 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA32_RS26885 (153266) 153266..153493 + 228 WP_169051904.1 toxin-antitoxin system antitoxin VapB Antitoxin
QQA32_RS26890 (153493) 153493..153891 + 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
QQA32_RS26895 (153900) 153900..156053 - 2154 WP_000009379.1 type IV conjugative transfer system coupling protein TraD -
QQA32_RS26900 (156306) 156306..157037 - 732 WP_000850416.1 conjugal transfer complement resistance protein TraT -
QQA32_RS26905 (157051) 157051..157560 - 510 WP_000628105.1 conjugal transfer entry exclusion protein TraS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat 1..193604 193604


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T283039 WP_000911333.1 NZ_CP126927:153493-153891 [Escherichia coli O2:K1:H5]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8654.67 Da        Isoelectric Point: 4.5680

>AT283039 WP_169051904.1 NZ_CP126927:153266-153493 [Escherichia coli O2:K1:H5]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPDMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References