Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4752681..4753178 Replicon chromosome
Accession NZ_CP126926
Organism Escherichia coli O2:K1:H5 strain APEC E19035

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQA32_RS23480 Protein ID WP_001173343.1
Coordinates 4752681..4752854 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QQA32_RS23485 Protein ID WP_001312331.1
Coordinates 4752882..4753178 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA32_RS23470 (4749351) 4749351..4750808 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QQA32_RS23475 (4751045) 4751045..4752562 + 1518 WP_000003806.1 lysine--tRNA ligase -
QQA32_RS23480 (4752681) 4752681..4752854 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQA32_RS23485 (4752882) 4752882..4753178 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQA32_RS23490 (4753407) 4753407..4753679 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQA32_RS23495 (4753691) 4753691..4753921 - 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
QQA32_RS23500 (4754102) 4754102..4755733 + 1632 WP_001216482.1 sensor histidine kinase -
QQA32_RS23505 (4755730) 4755730..4756449 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283032 WP_001173343.1 NZ_CP126926:c4752854-4752681 [Escherichia coli O2:K1:H5]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT283032 WP_001312331.1 NZ_CP126926:c4753178-4752882 [Escherichia coli O2:K1:H5]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References