Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3784791..3785409 Replicon chromosome
Accession NZ_CP126926
Organism Escherichia coli O2:K1:H5 strain APEC E19035

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QQA32_RS18670 Protein ID WP_001291435.1
Coordinates 3785191..3785409 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QQA32_RS18665 Protein ID WP_000344800.1
Coordinates 3784791..3785165 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA32_RS18655 (3779881) 3779881..3781074 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QQA32_RS18660 (3781097) 3781097..3784246 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QQA32_RS18665 (3784791) 3784791..3785165 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QQA32_RS18670 (3785191) 3785191..3785409 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QQA32_RS18675 (3785583) 3785583..3786134 + 552 WP_000102543.1 maltose O-acetyltransferase -
QQA32_RS18680 (3786250) 3786250..3786720 + 471 WP_000136192.1 YlaC family protein -
QQA32_RS18685 (3786884) 3786884..3788434 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QQA32_RS18690 (3788476) 3788476..3788829 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QQA32_RS18700 (3789208) 3789208..3789519 + 312 WP_000409908.1 MGMT family protein -
QQA32_RS18705 (3789550) 3789550..3790122 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T283028 WP_001291435.1 NZ_CP126926:3785191-3785409 [Escherichia coli O2:K1:H5]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT283028 WP_000344800.1 NZ_CP126926:3784791-3785165 [Escherichia coli O2:K1:H5]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References