Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2713567..2715155 Replicon chromosome
Accession NZ_CP126926
Organism Escherichia coli O2:K1:H5 strain APEC E19035

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag QQA32_RS13315 Protein ID WP_001125475.1
Coordinates 2713833..2715155 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QQA32_RS13310 Protein ID WP_001332145.1
Coordinates 2713567..2713833 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA32_RS13295 (2709935) 2709935..2711386 + 1452 WP_000854637.1 tagaturonate reductase -
QQA32_RS13300 (2711583) 2711583..2712497 + 915 WP_103433013.1 bestrophin family protein -
QQA32_RS13305 (2712501) 2712501..2713259 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
QQA32_RS13310 (2713567) 2713567..2713833 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QQA32_RS13315 (2713833) 2713833..2715155 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QQA32_RS13320 (2715465) 2715465..2715647 - 183 Protein_2613 hypothetical protein -
QQA32_RS13325 (2715781) 2715781..2716563 + 783 WP_001221834.1 SDR family oxidoreductase -
QQA32_RS13330 (2716807) 2716807..2716914 - 108 Protein_2615 hypothetical protein -
QQA32_RS13335 (2717339) 2717339..2717902 + 564 WP_039267869.1 type 1 fimbrial major subunit FimA -
QQA32_RS13340 (2718264) 2718264..2718974 + 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(149-401)

Antitoxin

(18-69)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T283025 WP_001125475.1 NZ_CP126926:2713833-2715155 [Escherichia coli O2:K1:H5]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT283025 WP_001332145.1 NZ_CP126926:2713567-2713833 [Escherichia coli O2:K1:H5]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8


Antitoxin

Source ID Structure

References