Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2713567..2715155 | Replicon | chromosome |
Accession | NZ_CP126926 | ||
Organism | Escherichia coli O2:K1:H5 strain APEC E19035 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | B7MMY1 |
Locus tag | QQA32_RS13315 | Protein ID | WP_001125475.1 |
Coordinates | 2713833..2715155 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | QQA32_RS13310 | Protein ID | WP_001332145.1 |
Coordinates | 2713567..2713833 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QQA32_RS13295 (2709935) | 2709935..2711386 | + | 1452 | WP_000854637.1 | tagaturonate reductase | - |
QQA32_RS13300 (2711583) | 2711583..2712497 | + | 915 | WP_103433013.1 | bestrophin family protein | - |
QQA32_RS13305 (2712501) | 2712501..2713259 | - | 759 | WP_001286588.1 | trans-aconitate 2-methyltransferase | - |
QQA32_RS13310 (2713567) | 2713567..2713833 | + | 267 | WP_001332145.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
QQA32_RS13315 (2713833) | 2713833..2715155 | + | 1323 | WP_001125475.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
QQA32_RS13320 (2715465) | 2715465..2715647 | - | 183 | Protein_2613 | hypothetical protein | - |
QQA32_RS13325 (2715781) | 2715781..2716563 | + | 783 | WP_001221834.1 | SDR family oxidoreductase | - |
QQA32_RS13330 (2716807) | 2716807..2716914 | - | 108 | Protein_2615 | hypothetical protein | - |
QQA32_RS13335 (2717339) | 2717339..2717902 | + | 564 | WP_039267869.1 | type 1 fimbrial major subunit FimA | - |
QQA32_RS13340 (2718264) | 2718264..2718974 | + | 711 | WP_001195181.1 | fimbria/pilus periplasmic chaperone | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49426.24 Da Isoelectric Point: 8.9380
>T283025 WP_001125475.1 NZ_CP126926:2713833-2715155 [Escherichia coli O2:K1:H5]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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