Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1034629..1035283 Replicon chromosome
Accession NZ_CP126926
Organism Escherichia coli O2:K1:H5 strain APEC E19035

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QQA32_RS05110 Protein ID WP_000244781.1
Coordinates 1034876..1035283 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QQA32_RS05105 Protein ID WP_000354046.1
Coordinates 1034629..1034895 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA32_RS05085 (1030717) 1030717..1032150 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
QQA32_RS05090 (1032195) 1032195..1032506 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QQA32_RS05095 (1032670) 1032670..1033329 + 660 WP_000250274.1 hemolysin III family protein -
QQA32_RS05100 (1033406) 1033406..1034386 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
QQA32_RS05105 (1034629) 1034629..1034895 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QQA32_RS05110 (1034876) 1034876..1035283 + 408 WP_000244781.1 protein YgfX Toxin
QQA32_RS05115 (1035323) 1035323..1035844 - 522 WP_001055874.1 flavodoxin FldB -
QQA32_RS05120 (1035956) 1035956..1036852 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
QQA32_RS05125 (1036877) 1036877..1037587 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QQA32_RS05130 (1037593) 1037593..1039326 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T283019 WP_000244781.1 NZ_CP126926:1034876-1035283 [Escherichia coli O2:K1:H5]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT283019 WP_000354046.1 NZ_CP126926:1034629-1034895 [Escherichia coli O2:K1:H5]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References