Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1516866..1517642 Replicon chromosome
Accession NZ_CP126631
Organism Staphylococcus aureus strain 33-40

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QPR37_RS07645 Protein ID WP_000031108.1
Coordinates 1517490..1517642 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag QPR37_RS07640 Protein ID WP_063652486.1
Coordinates 1516866..1517465 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPR37_RS07620 (QPR37_07620) 1512781..1514238 + 1458 WP_259378840.1 ABC transporter permease subunit -
QPR37_RS07625 (QPR37_07625) 1514231..1514953 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
QPR37_RS07630 (QPR37_07630) 1515104..1516231 + 1128 WP_063652481.1 tRNA epoxyqueuosine(34) reductase QueG -
QPR37_RS07635 (QPR37_07635) 1516236..1516742 + 507 WP_063652483.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QPR37_RS07640 (QPR37_07640) 1516866..1517465 + 600 WP_063652486.1 hypothetical protein Antitoxin
QPR37_RS07645 (QPR37_07645) 1517490..1517642 + 153 WP_000031108.1 SAS053 family protein Toxin
QPR37_RS07650 (QPR37_07650) 1518302..1518697 + 396 WP_063652488.1 hypothetical protein -
QPR37_RS07655 (QPR37_07655) 1518893..1520278 + 1386 WP_063652489.1 class II fumarate hydratase -
QPR37_RS07660 (QPR37_07660) 1520727..1521548 - 822 WP_000669377.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T283000 WP_000031108.1 NZ_CP126631:1517490-1517642 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.54 Da        Isoelectric Point: 5.3978

>AT283000 WP_063652486.1 NZ_CP126631:1516866-1517465 [Staphylococcus aureus]
MAMNFKVFDNSKLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References